The U.S. Environmental Protection Agency and the U.S. Department of Energy released a Funding Opportunity Announcement (FOA) for up to $9.4 million for the development of advanced biofuels. This investment through a new agreement between EPA and DOE is funded by President Biden’s Inflation Reduction Act and will support high-impact biofuel technology projects to improve the performance and reduce the cost of biofuel production technologies, scale up production systems in partnership with industry, and accelerate the nation’s bioeconomy. This FOA has two topic areas: (1) Pre-Pilot Scale-Up of Integrated Biorefinery Technologies, and (2), Biointermediate Processing Toolbox.